Submitted by stabberfarflung on 05/30/2024 - 04:07.
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Evidence is increasing that addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both after they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err to the side of caution and allow FDA do its job and demand some study be done in order that the public knows the side effects and hazards of the medications before we drive them. Keep in mind that drug companies are in business to make money and that they would say almost anything to keep people on his or her medications.
Researchers found that participants taking this drug for any year, dropped excess weight within a month and have kept the weight off throughout the 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which are made up of multiple active ingredient, which can make them more potent and safer.
Combo-pilling is the newest fad or also the newest in the future under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular may be the fact that by right now there aren't any long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA.
Seizures can be a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise blood pressure and pulse rate, and must not be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.
The FDA also warned that Contrave can raise blood pressure level and heart rate and must stop used in patients with uncontrolled high hypertension, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients on the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.
"This could be the first drug I'm alert to that targets the appetite and reward centres within the brain," he was quoted saying.